Cannabis MOC

Hub

• Cannabis

Mechanisms

• CB1 receptor — primary THC target; downregulation drives tolerance and withdrawal
• 11-OH-THC — active metabolite; explains edible potency and duration

Biometrics

• HRV signatures — acute ↓ sympathetic; chronic baseline ↑ paradoxically
• REM suppression — strongest consistent sleep signature; ~34 min same-night reduction
• Sleep architecture — subjective ease ≠ objective quality; REM/N3 distortion

Risks

• Psychosis risk — dose/potency-dependent; OR 1.4–5.7
• Cardiovascular risk — RR 1.2–2.1 for ACS/stroke/CV death; smoked strongest
• CHS — paradoxical vomiting from TRPV1 desensitization

Recovery

• Cannabis withdrawal — onset 1–2 days; peak day 3; full resolution ~30 days; CB1 recovery lag + endocannabinoid tone collapse

Detection

• Cannabis detection model — HR delta + REM + motion context; AUC ~0.75–0.85 occasional users

Interactions

• Cannabis peptide interactions — goal conflict with Retatrutide appetite suppression; no PK interactions with BPC-157/TB-500/GHK-Cu